生物通报道:来自中国科学院昆明动物所细胞与分子进化重点实验室(Key Laboratory of Cellular and Molecular Evolution),昆明灵长类研究中心(Kunming Primate Research Center)等处的研究人员通过对灵长类代表物种的研究,发现了一个快速进化的microRNA家族,这为研究蛋白编码基因的进化模式及其在功能进化中的作用提供崭新的视角。这一研究成果公布在《Genome Research》杂志(影响因子10.139)上。 领导这一研究是来自中科院昆明动物所宿兵博士,其早年毕业于武汉大学,之后于美国德克萨斯大学修斯顿人类遗传学中心进行博士后研究工作,目前任中国科学院昆明动物所研究员,细胞与分子进化重点实验室主任。
原文检索:
Genome Research, DOI: 10.1101/gr.6146507
Published online before print April 6, 2007
Rapid evolution of an X-linked microRNA cluster in primates [Abstract]
Rui Zhang1,2,3, Yi Peng1,2, Wen Wang1, and Bing Su 1,2,4
1 Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; 2 Kunming Primate Research Center, Chinese Academy of Sciences, Kunming 650223, China; 3 Graduate School of Chinese Academy Sciences, Beijing 100039, China
中国农业大学与复旦大学合作研究成果在《GENOME RESEARCH》发表
2006年 5月1日出版的基因组学研究领域权威杂志《Genome Research》(影响因子:10.38),刊登了中国农业大学孙传清教授课题组和复旦大学杨金水教授课题组的合作研究论文:“Haplotype variation in structure and expression of a gene cluster associated with a quantitative trait locus for improved yield in rice”,标志着我国在野生稻基因组研究上取得了重要成果。
四年前,孙传清教授领导的课题组在被誉为“植物大熊猫”的江西东乡野生稻的第2染色体上发现了高产QTL(数量性状基因位点)。随后,孙传清教授课题组和复旦大学杨金水教授课题组通力合作,在国家科技部、农业部、自然科学基金委的支持下,经过3年的不懈努力,将高产QTL精细定位到102.9kb的区域。进一步的研究发现,这段序列是一个富含亮氨酸受体激酶基因簇的单倍型区域,通过单倍型区域的等位基因序列及基因表达分析,证明富含亮氨酸受体激酶基因簇是改良产量的候选基因。该项研究成果不仅为农作物复杂农艺性状基因组解析建立了一个新的技术平台,而且为我国超级稻育种提供重要的具有自主知识产权新基因,已经引起了国内外同行的广泛关注。 原文检索:
Genome Res., May 2006; 16: 618 - 626 ; doi:10.1101/gr.4814006
Haplotype variation in structure and expression of a gene cluster associated with a quantitative trait locus for improved yield in rice [Abstract]
Guangming He 1,6, Xiaojin Luo2,3,4,5,6, Feng Tian2,3,4,5, Kegui Li1, Zuofeng Zhu2,3,4,5,Wei Su 1, Xiaoyin Qian1, Yongcai Fu2,3,4,5, Xiangkun Wang2,3,4,5, ChuanqingSun2,3,4,5,7 and Jinshui Yang 1,7
1 State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China; 2 Department of Plant Genetics and Breeding and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100094, China; 3 Key Laboratory of Crop Heterosis and Utilization of Ministry of Education, Beijing 100094, China; 4 Beijing Key Laboratory of Crop Genetic Improvement, Beijing 100094, China; 5 Key Laboratory of Crop Genetic Improvement and Genome of Ministry of Agriculture, Beijing 100094, China.
《Genes & Development》杂志发表华中农业大学研究论文
国际知名学术杂志《Genes & Development》(《基因与发育》)2006年5月第10期刊发华中农业大学王石平教授研究小组的科研论文,《水稻花粉发育关键基因启动子突变导致水稻白叶枯病的抗性》(英文名《Promoter mutations of an essential gene for pollen development result in disease resistance in rice》)。
经过常达7年的艰苦工作,王石平教授的研究小组和国际合作者发现一种重要的新型水稻抗病基因——xa13。该基因在水稻中的存在不仅仅影响水稻对白叶枯病的抗性,同时也是花粉发育必不可少的重要基因。研究表明,xa13基因影响着水稻对白叶枯病的抗性和水稻的生长,是可以用于水稻遗传改良的重要基因之一。水稻对疾病的抵抗和有性生殖是其完成整个生长周期的基本能力。通常认为,这两个生物学特性是相互独立的,并由不同的基因所控制。
《Genes & Development》杂志由世界著名的冷泉港实验室(Cold Spring harbor Laboratory,简称CSHL)出版,刊登分子生物学、分子基因学以及相关领域内具有广泛意义的优秀学术论文,在分子生物学、细胞生物学等领域有着极大的影响,2004年该杂志SCI影响因子为16.385 。位于美国纽约长岛的冷泉港实验室被称为世界生命科学的圣地与分子生物学的摇篮,名列世界上影响最大的十大研究学院榜首。 原文检索:
Published online before print April 28, 2006
Genes and Development, DOI: 10.1101/gad.1416306 Promoter mutations of an essential gene for pollen development result in disease resistance in rice[Abstract]
Promoter mutations of an essential gene for pollen development result in disease resistance in rice
Zhaohui Chu1, Meng Yuan1, Jialing Yao1, Xiaojia Ge1, Bin Yuan1, Caiguo Xu1, Xianghua Li1, Binying Fu2,4, Zhikang Li2,4, Jeffrey L. Bennetzen3, Qifa Zhang1 and Shiping Wang1,5
1 National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China; 2 Plant Breeding, Genetics and Biotechnology Division, International Rice Research Institute, 1099 Manila, The Philippines; 3 Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray
原文检索:
Genome Res. Published September 4, 2007, 10.1101/gr.6611807
Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray [Abstract]
Housheng He 1,2,8, Jie Wang1,2,8, Tao Liu1,2,8, X. Shirley Liu3,4, Tiantian Li1,2, YunfeiWang1,2, Zuwei Qian5, Haixia Zheng1,2, Xiaopeng Zhu1,2, Tao Wu1,2, Baochen Shi1,2, Wei Deng 1, Wei Zhou5, Geir Skogerbø1,9, and Runsheng Chen1,6,7,9
1 Bioinformatics Laboratory and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2 Graduate School of the Chinese Academy of Science, Beijing 100080, China; 3 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA; 4 Harvard School of Public Health, Boston, Massachusetts 02115, USA; 5 Affymetrix, Inc., Santa Clara, California 95051, USA; 6 Bioinformatics Research Group, Key Laboratory of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Science, Beijing 100080, China; 7 Chinese National Human Genome Center, Beijing 100176, China |